The 3' region of Human Papillomavirus type 16 early mRNAs decrease expression
نویسندگان
چکیده
منابع مشابه
The 3' region of Human Papillomavirus type 16 early mRNAs decrease expression
BACKGROUND High risk human papillomavirus (HR-HPV) infects mucosal surfaces and HR-HPV infection is required for development of cervical cancer. Accordingly, enforced expression of the early HR-HPV proteins can induce immortalisation of human cells. In most cervical cancers and cervical cancer cell lines the HR-HPV double stranded DNA genome has been integrated into the host cell genome. METH...
متن کاملSplicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs
The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 earl...
متن کاملDeveloping Michigan Cancer Foundation 7 Cells with Stable Expression of E7 Gene of Human Papillomavirus Type 16
Background: Human papillomavirus (HPV) is responsible for the development of cervical neoplasia. Infection with human papillomavirus type 16 (HPV-16) is a major risk factor for the development of cervical cancer. The virus encodes three oncoproteins (E5, E6 and E7), of which, the E7 oncoprotein is the major protein involved in cell immortalization and transformation o...
متن کاملNFI is an Essential Positive Transcription Factor for Human Papillomavirus Type 16 Early Gene Expression
Human papillomavirus type 16 (HPV16) is the primary etiologic agent for greater than 50% of all cervical carcinomas. Expression of the HPV16 E6 and E7 oncoproteins is under control of the upstream regulatory region (URR), which contains a myriad of transcription factor binding sites, including 7 half sites for NFI. These NFI binding sites were used as probes in electrophoretic mobility shift as...
متن کاملThe chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression.
The long control region (LCR) of human papillomavirus type 16 (HPV-16) has a size of 850 bp (about 12% of the viral genome) and regulates transcription and replication of the viral DNA. The 5' segment of the LCR contains transcription termination signals and a nuclear matrix attachment region, the central segment contains an epithelial cell-specific enhancer, and the 3' segment contains the rep...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2005
ISSN: 1471-2334
DOI: 10.1186/1471-2334-5-83